genetic mutation

noun

plural genetic mutations

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.

—Natalie Angier

Examples of genetic mutation in a Sentence

Recent Examples on the Web

Because iPS cells can be generated from individual patients, researchers can study diseases using cells that carry a patient’s own genetic mutations and investigate personalized treatments. — Encyclopedia Britannica, 10 July 2026

The autopsy and other testing revealed that the Wahls have a genetic mutation that predisposes them to aortic ruptures. — Pj Green, Kansas City Star, 8 July 2026

Researchers also introduced a genetic mutation that allowed some synthetic cells to grow faster than others. — Greg Wehner, FOXNews.com, 3 July 2026

Researchers are now identifying causes that were invisible before, from noise exposure habits to rare genetic mutations. — Allison Palmer, Miami Herald, 1 July 2026

Word History

First Known Use

1915, in the meaning defined above

Rhymes for genetic mutation

• acclimatisation
• acclimatization
• acidification
• actualization
• annualization
• autocorrelation
• autoregulation
• beatification
• beneficiation
• biodegradation
• biotransformation
• bureaucratization

Medical Definition

genetic mutation

noun

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.

—Joseph Alper