genetic mutation

noun

plural genetic mutations

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.

—Natalie Angier

Examples of genetic mutation in a Sentence

Recent Examples on the Web

Jaxson’s genetic mutation is under the umbrella of Leigh syndrome. — Ciara McCarthy 22, Fort Worth Star-Telegram, 22 Oct. 2026

This cancer is caused by the accumulation of certain genetic mutations that prevent rectal cells from repairing DNA damage and accounts for 5-10% of rectal cancers. — Alice Park, Time, 21 Oct. 2026

Additional testing will be performed to determine staging and tumor features including genetic mutations, which guide treatment decisions. — ABC News, 14 Oct. 2026

Years passed before doctors solved the mystery, first attributing the behavioral changes to frontotemporal dementia (FTD), then linking that rare condition to a genetic mutation. — The Week Us, TheWeek, 13 Oct. 2026

Word History

First Known Use

1915, in the meaning defined above

Rhymes for genetic mutation

• acclimatisation
• acclimatization
• acidification
• actualization
• annualization
• autocorrelation
• autoregulation
• beatification
• beneficiation
• biodegradation
• biotransformation
• bureaucratization

Medical Definition

genetic mutation

noun

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.

—Joseph Alper